EN | TR
E-ISSN: 2146-3077
<i>Demodex</i> Infestation in Patients with Rosacea
PDF
Cite
Share
Request
Original Investigation
VOLUME: 43 ISSUE: 4
P: 194-197
December 2019

Demodex Infestation in Patients with Rosacea

Turkiye Parazitol Derg 2019;43(4):194-197
DOI: 10.4274/tpd.galenos.2019.6456
Dursun Türkmen 1
Gamze Türkoğlu 2
1. Malatya Eğitim ve Araştırma Hastanesi, Dermotoloji Kliniği, Malatya, Türkiye
2. Malatya Eğitim ve Araştırma Hastanesi, Mikrobiyoloji Kliniği, Malatya, Türkiye
No information available.
No information available
Received Date: 03.06.2019
Accepted Date: 09.09.2019
Publish Date: 18.12.2019
PDF
Cite
Share
Request

ABSTRACT

Objective:

Although the etiology of rosacea is not known exactly, it is thought as a multifactorial disease. Demodex spp. are asymptomatic saprophytic ectoparasites living in hair follicles and sebaceous glands. The aim of this study was to investigate the frequency of Demodex spp. in patients with rosacea and compare with the control group by using superficial skin biopsy method.

Methods:

Seventy seven patients with rosacea and 31 control patients were included in the study. In patients, for the determination of density of Demodex spp., non-invasive standard superficial skin biopsy method was applied. Detection of ≥5/cm2 Demodex spp. was considered positive.

Results:

The mean age of the patients was 44.5±14.6 years and the mean age of the control group was 48.2±14.9 years. Of the patients, 55.1% had erythema-telangiectatic type, 43.5% had papulopustular type, and 3.9% had fimatous type lesions. Demodex infestation was positive in 33.8% of the patients with rosacea and this rate was 9.7% in the control group. Difference was statistically significant. There was no significant difference in Demodex spp. positivity in terms of gender in patients with rosacea.

Conclusion:

The importance of Demodex infestation in patients with rosacea has been increasing in recent years. Considering some studies conducted in our country, we think that the investigation of Demodex spp. in patients who are considered to have rosacea will be beneficial in the terms of early diagnosis and treatment.

Keywords: Rosacea, Demodex spp., dermatosis, infestation

References

1
Gallo RL, Granstein RD, Kang S, Mannis M, Steinhoff M, Tan J, et al. Standard classification and pathophysiology of rosacea: The 2017 update by the National Rosacea Society Expert Committee. J Am Acad Dermatol 2018;78:148-55.
2
Jones DA. Rosacea, reactive oxygen species, and azelaic acid. J Clin Aesthet Dermatol 2009;2:26-30.
3
Woo YR, Lim JH, Cho DH, Park HJ. Rosacea: Molecular Mechanisms and Management of a Chronic Cutaneous Inflammatory Condition. Int J Mol Sci 2016;17:1562.
4
Steinhoff M, Schauber J, Leyden JJ. New insights into rosacea pathophysiology: a review of recent findings. J Am Acad Dermatol 2013;69:15-26.
5
Vemuri RC, Gundamaraju R, Sekaran SD, Manikam R. Major pathophysiological correlations of rosacea: a complete clinical appraisal. Int J Med Sci 2015;12:387-96.
6
Erbağcı Z. Rozasea: Sınıflama ve Etyopatogenezde Son Görüşler. Türkiye Klinikleri J Dermatol 2005;15:105-16.
7
Baima B, Sticherling M. Demodicidosis revisited. Acta Derm Venereol 2002;82:3-6.
8
Roihu T, Kariniemi AL. Demodex mites in acne rosacea. J Cutan Pathol 1998;25:550-2.
9
Basta-Juzbasic A, Subic JS, Ljubojevic S. Demodex folliculorum in development of dermatitis rosaceiformis steroidica and rosacea-related diseases. Clin Dermatol 2002;20:135-40.
10
Jansen T, Kastner U, Kreuter A, Altmeyer P. Rosacea-like demodicidosis associated with acquired immunodeficiency syndrome ( case reports). Br J Dermatol 2001;144:139-42.
11
Stephen MP, Thomas JH, Steven LD. Pustular folliculitis associated with Demodex folliculorum. J Am Acad Dermatol 1986;15:1159-62.
12
Forstinger C,Kitler H,Binder M. Treatment of rosacea-like demodecidosis with oral ivermectin and topical permethrin cream. J Am Acad Dermatol 1999;41:775-7.
13
Rufli T, Mumcuoğlu Y. The hair follicle mites D. folliculorum and D. brevis: biology and medical importance. Dermatology 1981;162:1-11.
14
Bonnar E, Eustace P, Powell FC. The Demodex mite population in rosacea. J Am Acad Dermatol 1993;28:443-8.
15
Özçelik S. Parazitoloji’de artropod hastalıkları ve vektörler. Editörler, Özcel MA, Daldal N. İzmir: Ege Üniversitesi Basımevi; 1997.s.339-62.
16
Erbağcı Z, Özgöztaşı O. The significance of Demodex folliculorum density in rosacea. Int J Dermatol 1998;37421-5.
17
Isa NHM, Loong LW, Fang GH, Mohamad AM, Razali N, Rani NR, et al. Demodicosis among university medical students in Malaysia and the effects of facial cleanser and moisturizer usage. S Asian J Trop Med Public Health 2011;42:1375-80.
18
Roihu T, Kariniemi AL. Demodex mites in acne rosacea. J Cutan Pathol 1998;25:550-2.
19
Forton F, Seys B. Density of Demodex folliculorum in rosacea: a case-control study using standardized skin-surface biopsy. Br J Dermatol 1993;128:650-9.
20
Abd-El-Al AM, Bayoumy AM, Abou Salem EA. A studyon Demodex folliculorum in rosacea. J Egypt S Parasitol 1997;27:183-95.
21
Sibenge S, Gawkrodger DJ. Rozasea: a study of clinical patterns, blood flow, and the role of DF. J Am Acad Dermatoll 1992;26:590-3.
22
Cengiz ZT, Yılmaz H, Özkol HU, Ekici A, Ödemiş N. Yüzüncü Yıl Üniversitesi Dursun Odabaş Tıp Merkezi Parazitoloji Laboratuarına Başvuran Hastalarda Demodex sp.’nin Prevalansı. Turkiye Parazitol Derg 2014;38:9-11.
23
Yücel A, Yilmaz M. Rosacea Ön Tanılı Hastalarda Demodex folliculorum ve Demodex brevis Yaygınlığının Araştırılması. Türkiye Parazitol Derg 2013;37:195-8.
24
Turan N, Kapıcıoğlu Y, Saraç G. Akne Vulgaris ve Rozase Hastalarında Deri Sebum, pH ve Nem Değerlerinin Demodeks Enfestasyonuna Etkisi. Türkiye Parazitol Derg 2017;41:143-7.
25
Georgala S, Katoulis AC, Kylafis GD, Koumantaki-Mathioudaki E, Georgala C, Aroni K. Increased density of DF and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea. JEADV 2001;15:441-4.
2024 ©️ Galenos Publishing House