ABSTRACT

Plasmodium berghei ANKA 6653 isolates that cause malaria in rodents were cultured in BALB/c mice in this study. Each of the BALB/c mice were injected intraperitoneally with 0.3 ml from a stock solution containing 160.000 parasites/ml. Percentage values of parasitemia at day 3, 6, 9 and 15 after injection were recorded and graphed. The neurological signs after day 3 were recorded in this study. At the end of day 15, cerebral tissues of dead mice were taken and the accumulation of hemorrhages was investigated. A total of 97 inbred BALB/c mice weighing approximately 17-20 gr. were used in this study.

Keywords: Plasmodium berghei, cerebral malaria, BALB/c mice