Investigation of Serum Macrophage Migration Inhibitor Factor (MIF) Levels in Patients with Cutaneous Leishmaniasis

Turkiye Parazitol Derg 2005;29(3):145-148

1. Adnan Menderes Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Aydın

2. Adnan Menderes Üniversitesi, Tıp Fakültesi, Parazitoloji Anabilim Dalı, Aydın

3. Bone&Joint Research Unit, Barts and the London, Queen Mary School of Medicine & Dentistry, University of London, UK

4. Adnan Menderes Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Aydın

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Received Date: 04.03.2005

Accepted Date: 20.05.2005

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ABSTRACT

In this study, the possible role of MIF as an immunologic marker in cutaneous leishmaniasis was evaluated. Twenty patients with acute cutaneous leishmaniasis (CL) and 20 healthy subjects were included in the study. MIF serum levels were measured using a sandwich ELISA method. The MIF levels were 3.50 ± 7.07 ng/ml in the control group and 69.05 ± 149.48 ng/ml in the CL group (p<0,001). The increase in MIF levels in CL patients may be due to the stimulation of a T cell-mediated cellular immune response by Leishmania.

Keywords: Macrophage migration inhibitor factor (MIF), Leishmania

Investigation of Serum Macrophage Migration Inhibitor Factor (MIF) Levels in Patients with Cutaneous Leishmaniasis

ABSTRACT

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