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E-ISSN: 2146-3077
Comparative Analysis at the Nucleotide Level of the Genes Encoding the Lactate Dehydrogenase Enzyme of Plasmodium vivax and Plasmodium falciparum
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Original Investigation
VOLUME: 29 ISSUE: 3
P: 149-153
September 2005

Comparative Analysis at the Nucleotide Level of the Genes Encoding the Lactate Dehydrogenase Enzyme of Plasmodium vivax and Plasmodium falciparum

Turkiye Parazitol Derg 2005;29(3):149-153
Ekrem AKBULUT
Venhar ÇELİK
Dilek TURGUT BALIK
1. Fırat Üniversitesi, Fen-Edebiyat Fakültesi, Biyoloji Bölümü, Elazığ
No information available.
No information available
Received Date: 07.02.2005
Accepted Date: 14.03.2005
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ABSTRACT

In this study, the nucleotide sequence of the enzyme lactate dehydrogenase from Plasmodium vivax has been compared to the same enzyme from another malaria parasite Plasmodium falciparum. It was found that the identity between two sequences was 74.8%. The percentage of the GC value was found to be higher in the Plasmodium vivax lactate dehydrogenase (46.6%) than in that of Plasmodium falciparum (33%). The nucleotide sequence that corresponds to the 5 amino acid insertion in Plasmodium lactate dehydrogenase is also present in Plasmodium vivax. This site will be targeted in the design of novel antimalarials for Plasmodium vivax as has been for Plasmodium falciparum.

Keywords:
Lactate dehydrogenase, antimalarials, gene cloning, Plasmodium vivax, Plasmodium falciparum