Avrupa Tavşanlarında (Lepus europaeus) <i>Encephalitozoon cuniculi, Francisella tularensis</i> ve <i>Toxoplasma gondii</i> Zoonoz Hastalıklarının Seroprevalansı
PDF
Atıf
Paylaş
Talep
P: 171-175
Eylül 2021

Avrupa Tavşanlarında (Lepus europaeus) Encephalitozoon cuniculi, Francisella tularensis ve Toxoplasma gondii Zoonoz Hastalıklarının Seroprevalansı

Turkiye Parazitol Derg 2021;45(3):171-175
Bilgi mevcut değil.
Bilgi mevcut değil
Alındığı Tarih: 17.11.2020
Kabul Tarihi: 17.02.2021
Yayın Tarihi: 04.08.2021
PDF
Atıf
Paylaş
Talep

ÖZET

Amaç:

Avrupa tavşanları (Lepus europaeus) pek çok ülkede bulunan ve doğal yaşamda insanlarla bağlantısı olan en önemli hayvan türlerinden biridir. Tavşanlar; Encephalitozoon cuniculi, Francisella tularensis, Toxoplasma gondii gibi birçok zoonotik hastalığı taşıdığı için halk sağlığı açısından oldukça önemlidir. Bu çalışmanın amacı, bu tip enfeksiyonların yaygınlığını ve Türkiye’de tavşanların oluşturduğu potansiyel zoonotik riski göstermektir.

Yöntemler:

Kan örnekleri, tavşanlardan resmi av sezonunda toplanmıştır. Serum örnekleri; E. cuniculi için enzim bağlantılı immüno sorbent testi, T. gondii için Sabin-Feldman boya testi ve F. tularensis için ise mikroaglütinasyon testi kullanılarak, serolojik olarak incelenmiştir.

Bulgular:

Yapılan analiz sonucunda 42 tavşandan 1’inde (%2,4) E. cuniculi testi pozitif, 2’sinde (%4,8) T. gondii testi pozitif ve 1’inde (%2,4) F. tularensis testi pozitif olarak tespit edilmiştir.

Sonuç:

Bu çalışmada, Türkiye’de ilk kez yabani tavşanlarda anti-T. gondii ve anti-E. cuniculi antikorları serolojik olarak tespit edilmiştir. Bu ayrıca, tavşanlarda F. tularensis enfeksiyonunun seropozitifliği ile ilgili olarak bildirilen ilk çalışmadır. Çalışmada yer alan üç farklı zoonotik hastalığın sıklığı, diğer Avrupa ülkelerinde bildirilen bulgular ve diğer referanslı çalışmalarla da tutarlıdır.

References

1
Kruse H, Kirkemo AM, Handeland K. Wildlife as source of zoonotic infections. Emerg Infect Dis 2004; 10: 2067-72. 
2
Treml F, Pikula J, Bandouchova H, Horakova J. European brown hare as a potential source of zoonotic agents. Vet Med-Czech 2007; 52: 451-6.
3
Tsokana CN, Sokos C, Giannakopoulos A, Birtsas P, Valiakos G, Spyrou V, et al. European Brown hare (Lepus europaeus) as a source of emerging and re-emerging pathogens of Public Health importance: A review. Vet Med Sci 2020; 6: 550-64. 
4
Yücesan B, Babür C, Koç N, Sezen F, Kılıç S, Gürüz Y. Investigation of Anti-Toxoplasma gondii Antibodies in Cats Using Sabin-Feldman Dye Test in Ankara in 2016. Turkiye Parazitol Derg 2019; 43: 5-9. 
5
Jokelainen P, Isomursu M, Näreaho A, Oksanen A. Natural toxoplasma gondii infections in European brown hares and mountain hares in Finland: proportional mortality rate, antibody prevalence, and genetic characterization. J Wildl Dis 2011; 47: 154-63. 
6
Simon L, Fillaux J, Guigon A, Lavergne RA, Villard O, Villena I, Marty P, Pomares C; Toxoplasma p35 Study Group. Serological diagnosis of Toxoplasma gondii: analysis of false-positive IgG results and implications. Parasite 2020; 27: 7. 
7
Shin HG, Lee SE, Hong SH, Kim SM, Choi YK, Park HJ, et al. Prevalence of Toxoplasma gondii infection in rabbits of Korea by serological tests and nested polymerase chain reaction. J Vet Med Sci 2013; 75: 1609-13. 
8
Wang XL, Dong L, Zhang L, Lv Y, Li Q, Li HL. Seroprevalence and Genetic Characterization of Toxoplasma gondii In Naturally Infected Synanthropic Rodents In Yunnan Province, Southwestern China. J Parasitol 2018; 104: 383-7. 
9
Leblebicioglu H, Esen S, Turan D, Tanyeri Y, Karadenizli A, Ziyagil F, et al. Outbreak of tularemia: a case-control study and environmental investigation in Turkey. Int J Infect Dis 2008; 12: 265-9. 
10
Kılıç S. A General Overview of Francisella tularensis and the epidemiology of Tularemia in Turkey. FLORA 2010; 15: 37-58.
11
Gürcan S. Epidemiology of tularemia. Balkan Med J 2014; 31: 3-10. 
12
Sağlık Bakanlığı. Tularemi hastalığının kontrolü için saha rehberi. Temel Sağlık Hizmetleri Genel Müdürlüğü, Zoonotik Hastalıklar Daire Başkanlığı. Ankara, Şubat 2011. Available from: https://sbu.saglik.gov.tr/Ekutuphane/kitaplar/Tularemi%20Saha%20Rehberi.pdf
13
Otto P, Kohlmann R, Müller W, Julich S, Geis G, Gatermann SG, et al. Hare-to-human transmission of Francisella tularensis subsp. holarctica, Germany. Emerg Infect Dis 2015; 21: 153-5. 
14
Hocevar SN, Paddock CD, Spak CW, Rosenblatt R, Diaz-Luna H, Castillo I, et al. Microsporidiosis acquired through solid organ transplantation: a public health investigation. Ann Intern Med 2014; 160: 213-20.
15
Cox JC, Hamilton RC, Attwood HD. An investigation of the route and progression of Encephalitozoon cuniculi infection in adult rabbits. J Protozool 1979; 26: 260-5. 
16
Jordan C, Zajac AM, Lindsay DS. Encephalitozoon cuniculi Infection in Rabbits.Comp Cont Educ Pract 2006; 28: 108-16.
17
Demirtaş Y, Albayrak İ, Yılmaz A. Studies of ecomorphological variations of the European hare (Lepus europaeus) in Turkey. Arch Biol Sci 2013; 65: 559-66.
18
Özkan Ö, Yücesan B, Pekkaya S, Alçığır ME, Gürcan İS. Relationship between seropositivity of Encephalitozoon cuniculi and renal biochemical markers in clinically healthy rabbits. Ankara Üniv Vet Fak Derg 2019; 66: 197-04.
19
Büyük F, Şahin M, Çelebi Ö, Mor N, Çelebi B. Investigation of Francisella tularensis antibodies in dogs in Kars and Ankara Region. Turk Hij Den Biyol Derg 2012; 69: 83-8.
20
Künzel F, Joachim A. Encephalitozoonosis in rabbits. Parasitol Res 2010; 106: 299-309.
21
Bártová E, Marková J, Sedlák K. Prevalence of antibodies to Encephalitozoon cuniculi in European hares (Lepus europaeus). Ann Agric Environ Med 2015; 22: 674-6. 
22
Ashmawy KI, Abuakkada SS, Awad AM. Seroprevalence of antibodies to Encephalitozoon cuniculi and Toxoplasma gondii in farmed domestic rabbits in Egypt. Zoonoses Public Health 2011; 58: 357-64. 
23
Okewole EA. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in Nigeria. Onderstepoort J Vet Res 2008; 75: 33-8. 
24
Keeble EJ, Shaw DJ. Seroprevalence of antibodies to Encephalitozoon cuniculi in domestic rabbits in the United Kingdom. Vet Rec 2006; 158: 539-44. 
25
Lonardi C, Grilli G, Ferrazzi V, Dal Cin M, Rigolin D, Piccirillo A. Serological survey of Encephalitozoon cuniculi infection in commercially reared rabbit does in Northern Italy. Res Vet Sci 2013; 94: 295-8. 
26
Thomas C, Finn M, Twigg L, Deplazes P, Thompson RC. Microsporidia (Encephalitozoon cuniculi) in wild rabbits in Australia. Aust Vet J 1997; 75: 808-10.
27
Erbay A, Dokuzoğuz B, Baykam N, Güvener E, Diker S, Yıldırmak T. Ankara yöresinde tularemi. Turkish J Infect 2000; 14: 453-8.
28
Ulu Kılıç A, Kılıç S, Sencan I, Ciçek Şentürk G, Gürbüz Y, Tütüncü EE, et al. İç Anadolu Bölgesinde Francisella tularensis alt tür halorctica’ya Bağlı Su Kaynaklı Bir Tularemi Salgını [A water-borne tularemia outbreak caused by Francisella tularensis subspecies holarctica in Central Anatolia region]. Mikrobiyol Bul 2011; 45: 234-7. 
29
Maurin M, Gyuranecz M. Tularaemia: clinical aspects in Europe. Lancet Infect Dis 2016; 16: 113-124. 
30
Akalin H, Helvaci S, Gedikoğlu S. Re-emergence of tularemia in Turkey. Int J Infect Dis 2009; 13: 547-51.
31
Ozsan K, Fazh A, Aktan M, Beyoğlu K. Ankara, Konya, Urfa ve Nevşehir’de yakalanan yabani hayvanlarda tularemi, brucellosis ve borreliosis yönünden araştirma [Brucellosis, tularemia and borreliosis isolated from wild animals captured in Ankara, Konya, Urfa and Nevsehir provinces in Turkey]. Mikrobiyol Bul 1976; 10: 413-21. 
32
Gürcan S, Eskiocak M, Varol G, Uzun C, Tatman-Otkun M, Sakru N, et al. Tularemia re-emerging in European part of Turkey after 60 years. Jpn J Infect Dis 2006; 59: 391-3. 
33
Winkelmayer R, Vodnansky M, Paulsen P, Gansterer A, Treml F. Explorative study on the seroprevalence of Brucella, Francisella and Leptospira antibodies in the European hare (Lepus Europaeus Pallas) of the Austrian-Czech border region. Wien Tierarztl Monat 2005; 92: 131-5.
34
Gyuranecz M, Erdélyi K, Makrai L, Fodor L, Szépe B, Mészáros AR, et al. Brucellosis of the European brown hare (Lepus europaeus). J Comp Pathol 2011; 145: 1-5. 
35
Höflechner-Pöltl A, Hofer E, Awad-Masalmeh M, Müller M, Steineck T. Tularämie und Brucellosebei Feldhasen und Füchsen in Österreich. Tierärztl Umschau 2000; 55: 264-68.
36
Frölich K, Wisser J, Schmüser H, Fehlberg U, Neubauer H, Grunow R, et al. Epizootiologic and ecologic investigations of European brown hares (Lepus europaeus) in selected populations from Schleswig-Holstein, Germany. J Wildl Dis 2003; 39: 751-61.
37
Dubey JP, Beattie CP. Toxoplasmosis of animals and man. Boca Raton, USA. CRC Press. 1988. p. 1-232.
38
Montazeri M, Mikaeili Galeh T, Moosazadeh M, Sarvi S, Dodangeh S, Javidnia J, et al. The global serological prevalence of Toxoplasma gondii in felids during the last five decades (1967-2017): a systematic review and meta-analysis. Parasit Vectors 2020; 13: 82. 
39
Kolören Z, Dubey JP. A review of toxoplasmosis in humans and animals in Turkey. Parasitology 2020; 147: 12-28.
40
Karakavuk M, Aldemir D, Mercier A, Atalay Şahar E, Can H, Murat JB, et al. Prevalence of toxoplasmosis and genetic characterization of Toxoplasma gondii strains isolated in wild birds of prey and their relation with previously isolated strains from Turkey. PLoS One 2018; 13: e0196159. 
41
Walton BC, De Arjona I, Benchoff BM. Relationship of Toxoplasma antibodies to altitude. Am J Trop Med Hyg 1966; 15: 492-5. 
42
Walls KW, Bullock SL, English DK. Use of the enzyme-linked immunosorbent assay (ELISA) and its microadaptation for the serodiagnosis of toxoplasmosis. J Clin Microbiol 1977; 5: 273-7. 
43
Balsari A, Poli G, Molina V, Dovis M, Petruzzelli E, Boniolo A, et al. ELISA for toxoplasma antibody detection: a comparison with other serodiagnostic tests. J Clin Pathol 1980; 33: 640-3. 
44
Liu Q, Wang ZD, Huang SY, Zhu XQ. Diagnosis of toxoplasmosis and typing of Toxoplasma gondii. Parasit Vectors 2015; 8: 292. 
45
Tsokana CN, Sokos C, Giannakopoulos A, Birtsas P, Athanasiou LV, Valiakos G, et al. Serological and molecular investigation of selected parasitic pathogens in European brown hare (Lepus europaeus) in Greece: inferring the ecological niche of Toxoplasma gondii and Leishmania infantum in hares. Parasitol Res 2019; 118: 2715-21. 
46
Bártová E, Sedlák K, Treml F, Holko I, Literák I. Neospora caninum and Toxoplasma gondii antibodies in European brown hares in the Czech Republic, Slovakia and Austria. Vet Parasitol 2010; 171: 155-8. 
47
Aubert D, Ajzenberg D, Richomme C, Gilot-Fromont E, Terrier ME, de Gevigney C, et al. Molecular and biological characteristics of Toxoplasma gondii isolates from wildlife in France. Vet Parasitol 2010; 171: 346-9. 
48
Gustafsson K, Uggla A. Serologic survey for Toxoplasma gondii infection in the brown hare (Lepus europaeus P.) in Sweden. J Wildl Dis 1994; 30: 201-4. 
2024 ©️ Galenos Publishing House