The Investigation of Malaria Cases in a Central Laboratory in İstanbul Region for a Period of Fifteen Years
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Original Investigation
P: 65-69
June 2019

The Investigation of Malaria Cases in a Central Laboratory in İstanbul Region for a Period of Fifteen Years

Turkiye Parazitol Derg 2019;43(2):65-69
1. Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji AD, İstanbul, Türkiye
2. Acıbadem Mehmet Ali Aydınlar Üniversitesi Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, İstanbul, Türkiye
3. Acıbadem Mehmet Ali Aydınlar Üniversitesi Tıp Fakültesi, Dönem V, İstanbul, Türkiye
4. Acıbadem Labmed Tıbbi Laboratuvarları Mikrobiyoloji Bölümü, İstanbul, Türkiye
5. Acıbadem Mehmet Ali Aydınlar Üniversitesi, Tıp Fakültesi, Dönem V, İstanbul, Türkiye
No information available.
No information available
Received Date: 22.03.2018
Accepted Date: 06.03.2019
Publish Date: 13.06.2019
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ABSTRACT

Objective:

The aim of this study is to examine the cases with malaria identified in the last 15 years in a central laboratory in Istanbul and assess their clinical features in general.

Methods:

A retrospective examination of the laboratory records of all malaria-suspected patients whose thin and thick smears of blood samples were examined between 2002 and 2017 was conducted. Cases diagnosed as having malaria were evaluated in terms of their personal features such as age and gender, complaints and findings at the time of diagnosis, clinical features and recent travel history to an endemic region.

Results:

Blood smears of 2271 patients were examined and Plasmodium spp. were detected in a total of 42 cases during the abovementioned period. Among these 42 cases, Plasmodium falciparum was detected in 19, Plasmodium ovale in 1 and Plasmodium vivax in 22 cases. It was noted that 32 of 42 cases were diagnosed in the last five years, and were infected during journey to Africa. July was found to be the month with highest number of cases.

Conclusion:

Almost all cases with malaria were imported cases due to P. vivax or P. falciparum, as expected. It is remarkable that, the demand for blood smear examinations due to the suspicion of malaria by physicians has increased and the number of cases with malaria detected in the laboratory has increased too, in recent years.

Keywords: Malaria, Plasmodium spp., Plasmodium falciparum, Istanbul, Turkey

References

1
Breman JG. Eradicating malaria. Sci Prog 2009;92:1-38.
2
Phillips MA, Burrows JN, Manyando C, van Huijsduijnen RH, Van Voorhis WC, Wells TNC. Malaria. Nat Rev Dis Primers 2017;3:17050.
3
WHO. World malaria report 2017. 2017; ISBN: 978 92 4 156552 3 (online). Available from: URL: http://apps.who.int/iris/bitstream/10665/259492/1/9789241565523-eng.pdf.
4
Gautret P, Cramer JP, Field V, Caumes E, Jensenius M, Gkrania-Klotsas E, et al.; Infectious diseases among travellers and migrants in Europe, EuroTravNet 2010. Euro Surveill 2012;28:17:pii 20205.
5
Hwang J, Cullen KA, Kachur SP, Arguin PM, Baird JK. Severe morbidity and mortality risk from malaria in the United States, 1985-2011. Open Forum Infect Dis 2014;1:ofu034.
6
Piyal B, Akdur R, Ocaktan E, Yozgatligil C. An analysis of the prevalence of malaria in Turkey over the last 85 years. Pathog Glob Health 2013;107:30-4.
7
Willcox ML, Mant J, O’Dempsey T. Imported malaria. BMJ 2013;346:f3214.
8
Färnert A, Wyss K, Dashti S, Naucler P. Duration of residency in a non-endemic area and risk of severe malaria in African immigrants. Clin Microbiol Infect 2015;21:494-501.
9
Murray CK, Gasser RA Jr, Magill AJ, Miller RS. Update on rapid diagnostic testing for malaria. Clin Microbiol Rev 2008;21:97-110.
10
Özbilgin A, Tamay AT. Sıtma tanısında yenilikler. Ankem Derg 2000;14:260-5.
11
CDC. Malaria, 2017 (online). Available from: URL: https://www.cdc.gov/malaria/
12
Çetinkaya Z, Özçelik R. Afyon›da Sıtma Epidemiyolojisi. Türkiye Parazitol Derg 2004;28:77-9.
13
Sarı C, Sakarya S, Ertabaklar H, Öncü S, Ertuğ S. Aydın İlinde 2001-2003 Yılları Arasında Saptanan Sıtma Olgularının Değerlendirilmesi. Türkiye Parazitol Derg 2004 28:119-122.
14
Alver O, Yılmaz E, Akçağlar S, Töre O. Malaria in Bursa. Türkiye Parazitol Derg 2007;31:249-55.
15
Temiz H, Gül K. 1999-2004 Yıllarında Diyarbakır’da Saptanan Sıtma Olgularının Değerlendirilmesi. Turkiye Parazitol Derg 2006;30:261-4.
16
Kuk S, Özden M. Kaplan M. Elazığ’da 1996-2004 yılları arasında sıtma epidemiyolojisi. Türkiye Parazitol Derg 2006;30:265-7.
17
Sönmez TG. Kocaeli’de Sıtma Epidemiyolojisi, Türkiye Parazitol Derg 2008;32:313-6.
18
Atambay M, Karaman Ü, Yaşar S, Aycan ÖM, Daldal N. Malatya’da Aktif Sürveyans ile Saptanan Sıtma Vakaları. Türkiye Parazitol Derg 2006;30:86-8.
19
Östan İ, Limoncu ME, Tüysüz MA, Köroğlu G, Özbilgin A. Manisa ilinde 2002-2004 yılları arasında saptanan sıtma olgularının değerlendirilmesi. Türkiye Parazitol Derg 2006;30:89-91.
20
Zorbozan O, Pullukçu H, Atalay Şahar E, Karakavuk M, Can H, Tunali V, et al. The importance of the contribution of rapid test, serological and molecular methods in the diagnosis of two imported malaria cases with atypical microscopy. Mikrobiyol Bul 2017;51:396-403.
21
Özbilgina A, Topluoğlu S, Es S, Islek E, Mollahaliloglu S, Erkoc Y. Malaria in Turkey: successful control and strategies for achieving elimination. Acta Trop 2011;120:15-23.
22
Özbilgin A, Çavuş İ, Yıldırım A, Gündüz C. The first monkey malaria in Turkey: a case of Plasmodium knowlesi. Mikrobiyol Bul 2016;50:484-90.
23
Hatipoğlu M, Ülçay A, Turhan V, Karagöz E, Erdem H, Acar A, et al. Dış kaynaklı iki relaps Plasmodium vivax olgusu ve profilakside primakin. Turkiye Parazitol Derg 2014;38:120-3.
24
Wongsrichanalai C, Sibley CH. Fighting drug-resistant Plasmodium falciparum: the challenge of artemisinin resistance. Clin Microbiol Infect 2013;19:908-16.
25
Price RN, von Seidlein L, Valecha N, Nosten F, Baird JK, White NJ. Global extent of chloroquine-resistant Plasmodium vivax: a systematic review and meta-analysis. Lancet Infect Dis 2014;14:982-91.
26
WHO. Guidelines for the treatment of malaria. Third edition April 2015 (online). Available from: URL: http://apps.who.int/iris/bitstream/10665/162441/1/9789241549127_eng.pdf.
27
Mumcu N, Demiraslan H, Dündar A, Kuk S, Yazar S, Doğanay M. A Case Series of Imported Malaria Caused by Plasmodium falciparum in Kayseri and Review of Literature. Turkiye Parazitol Derg 2017;41:119-22.
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