Retrospective Analysis of Cases with Imported Malaria in Hatay Province of Turkey: Seventy-Five Cases in Ten Years
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Original Investigation
P: 60-64
June 2019

Retrospective Analysis of Cases with Imported Malaria in Hatay Province of Turkey: Seventy-Five Cases in Ten Years

Turkiye Parazitol Derg 2019;43(2):60-64
1. Nusaybin Devlet Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Mardin, Türkiye
2. Hatay Mustafa Kemal Üniversitesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Hatay, Türkiye
3. Siirt Devlet Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Siirt, Türkiye
4. Hatay Mustafa Kemal Üniversitesi, Parazitoloji Anabilim Dalı, Hatay, Türkiye
No information available.
No information available
Received Date: 13.09.2018
Accepted Date: 06.03.2019
Publish Date: 13.06.2019
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ABSTRACT

Objective:

Cases with imported malaria have increased complication and mortality rates because of delayed diagnosis and treatment in non-endemic countries. This study aimed to investigate the incidence and clinical features of imported malaria in our clinic during the past 10 years.

Methods:

This retrospective study included 75 cases diagnosed as having imported malaria in our clinic between January 2008 and December 2017. The epidemiological data, laboratory findings, treatment data and clinical course of the cases were obtained from system records.

Results:

Patients were predominantly male (%98.6) with a median age of 51 (23-64) years. All cases were infected with Plasmodium falciparum, had a recent travel history to Sub-Saharan African countries and none had received chemoprophylaxis before travel. The incidence of imported malaria showed a declining trend after 2015. The most common findings were fever (100%), thrombocytopenia (84%) and anemia (72%). Although 8% of patients had presented with severe malaria, none of them died.

Conclusion:

Despite increasing incidence of imported malaria in our country in recent years, there is a decrease in this number in our region. Since Turkey is one of the countries with the highest prevalence of imported malaria in the world, patients with fever and thrombocytopenia should be questioned whether or not they had a history of travel to malaria-endemic area.

Keywords: Hatay, imported malaria, Plasmodium falciparum, thrombocytopenia

References

1
Fairhurst RM, Wellems TE. Malaria (Plasmodium Species). In: Bennet JE, Dolin R, Blaser MJ (eds). Mandell, Douglas and Bennett’s Principles and Practice of Infectious Disease. 8th ed. Philadelphia: Churchill Livingstone Elsevier; 2105.p.3437-62.
2
Gething PW, Patil AP, Smith DL, Guerra CA, Elyazar IR, Johnston GL, et al. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar J 2011;10:378.
3
World Health Organization. World Malaria Report. Geneva: World Health Organization;2017.
4
World Health Organization. World Malaria Report. Geneva: World Health Organization;2012.
5
Tatem A, Jia P, Ordanovich D, Falkner M, Huang Z, Howes R, et al. The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics. Lancet Infect Dis 2017;17:98-107.
6
Checkley AM, Smith A, Smith V, Blaze M, Bradley D, Chiodini PL, et al. Risk factors for mortality from imported falciparum malaria in the United Kingdom over 20 years: an observational study. BMJ 2012;344:e2116.
7
Andriopoulos P, Economopoulou A, Spanakos G, Assimakopoulos G. A local outbreak of autochthonous Plasmodium vivax malaria in Laconia, Greece--a re-emerging infection in the southern borders of Europe? Int J Infect Dis 2013;17:e125-8.
8
Sağmak Tartar A, Akbulut A. Epidemiological, Clinical, and Laboratory Evaluation of Plasmodium falciparum Malaria Cases Followed in Firat University Hospital: A 6-Year Retrospective Analysis. Turkiye Parazitol Derg 2018;42:1-5.
9
Önlen Y, Culha G, Ocak S, Savaş L, Güllü M. [Falciparum malaria originating in foreign country: four cases]. Turkiye Parazitol Derg 2007;31:256-9.
10
WHO Guidelines for the treatment of malaria. Third edition. 2015.
11
Berrevoets MA, Sprong T, Meis JF, Dofferhoff AS. Plasmodium falciparum malaria recrudescence occurring 2.5 years after leaving an endemic country. Neth J Med 2013;71:426-8.
12
Arends JE, Oosterheert JJ, Kraaij-Dirkzwager MM, Kaan JA, Fanoy EB, Haas PJ, et al. Two cases of Plasmodium falciparum malaria in the Netherlands without recent travel to a malaria-endemic country. Am J Trop Med Hyg 2013;89:527-30.
13
Szmitko PE, Kohn ML, Simor AE. Plasmodium falciparum malaria occurring 8 years after leaving an endemic area. Diagn Microbiol Infect Dis 2009;63:105-7.
14
Al Hammadi A, Mitchell M, Abraham GM, Wang JP. Recrudescence of Plasmodium falciparum in a Primigravida After Nearly 3 Years of Latency. Am J Trop Med Hyg 2017;96:642-44.
15
Ashley EA, Pyae Phyo A, Woodrow CJ. Malaria. Lancet. 2018 Apr 21;391:1608-21.
16
Christen D, Steffen R, Schlagenhauf P. Deaths caused by malaria in Switzerland 1988-2002. Am J Trop Med Hyg 2006;75:1188-94.
17
D’Acremont V, Landry P, Mueller I, Pécoud A, Genton B. Clinical and laboratory predictors of imported malaria in an outpatient setting: an aid to medical decision making in returning travelers with fever. Am J Trop Med Hyg 2002;66:481-6.
18
Lacerda MV, Mourão MP, Alexandre MA, Siqueira AM, Magalhães BM, Martinez-Espinosa FE, et al. Understanding the clinical spectrum of complicated Plasmodium vivax malaria: a systematic review on the contributions of the Brazilian literature. Malar J 2012;11:12.
19
World Health Organization. Severe Malaria. Trop Med Int Health 2014;19:7-131.
20
Lampah DA, Yeo TW, Malloy M, Kenangalem E, Douglas NM, Ronaldo D, et al. Severe malarial thrombocytopenia: a risk factor for mortality in Papua, Indonesia. J Infect Dis 2015;211:623-34.
21
Moses O, Nnodim Johnkennedy. The alteration of serum glucose, urea and creatinine level of malaria patients in Obowo Local Government Area of Imo State Nigeria. Int J Adv Med 2013;1:1-6
22
Abdul Manan J, Ali H, Lal M. Acute renal failure associated with malaria. J Ayub Med Coll Abbottabad 2006;18:47-52.
23
Mundhe R, Karale MS, Usendi C, Yadav S. Clinical profile and outcome of severe P. Falsiparum malaria. Int J Adv Med 2016;3:1034-38.
24
Raminez JH, Porras B, Borrero E, Martinez SP. Factors associated with the severity and complication of patients with malaria hospitalized between 2009 and 2013 in three municipalities of Colombia, case control study. Malar J 2016;15:514.
25
Anand AC, Puri P. Jaundice in malaria. J Gastroenterol Hepatol 2005;20:1322-32.
26
Asma UE, Taufiq F, Khan W. Prevalence and clinical manifestations of malaria in Aligarh, India. Korean J Parasitol 2014;52:621-9.
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