Dear Editor,
Novel zoonotic infections are a key source of concern in today’s clinical medicine (1). Monkeypox has spread throughout Europe, creating a significant public health risk (2). Monkeypox is a rare pox infection that has returned, most likely as a result of zoonosis (1). Monkeypox has spread over Europe, America and Asia, creating a significant public health risk (2). Monkeypox is an uncommon type of pox that has resurfaced, most likely due to zoonosis. The possibility of human-to-human transmission is being considered. The medical community is concerned as the number of reported cases in various countries climbs, and careful preparation to correspond the possible big outbreak is required. We must move swiftly and rapidly in order to conduct a full inquiry and put essential processes in place (2).
The western section of Africa, such as Nigeria, is the traditional endemic location for monkeypox infection. Malaria is a significant local public health issue in the same region. In this area, however, there has never been a report of co-infection or a concurrent outbreak. The authors analyse the pathophysiological pathways of both monkeypox and malaria using bioinformatic pathophysiological pathway analysis. The common path is investigated. This is the usual technique for understanding the pathophysiological process of virus infection that has been employed in prior pathophysiological pathway analysis studies (3).
The Golgi-to-endosome protein route was identified as a common pathway in both illnesses based on pathway analysis. Golgi-associated retrograde protein complex genes are involved in the double-membrane wrapping of monkeypox virus required for extracellular virus production in monkeypox, implicating the host endosomal trafficking pathway in orthopoxvirus infection (4). In asexual blood stage parasites, the hypothesised Golgi-to-endosome protein sorting pathway plays a role (5). Figure 1 is a diagram that depicts a common pathway. The current findings suggest that Plasmodium spp. and monkeypox share a natural competitive pathophysiological pathway, which could explain why there is no overlap or co-occurrence of the two important local infectious illnesses in endemic African countries.
*Ethics
Peer-review: Internally peer-reviewed.
* Authorship Contributions
Surgical and Medical Practices: R.M., V.W., Concept: R.M., V.W., Design: R.M., V.W., Data Collection or Processing: R.M., V.W., Analysis or Interpretation: R.M., V.W., Literature Search: R.M., V.W., Writing: R.M., V.W.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study received no financial support.
