ABSTRACT

Baculoviruses have become a noteworthy research and study material for various applications in recent years. They are used as insecticides in agriculture because of their high host specifity. Recombinant baculoviruses are being used in biotechnology for the expression of related genes under the control of strong polh and p10 genes promoters. They have attracted attention as gene therapy vectors in medicine. Baculoviruses can enter the mammalian cells; however, they neither replicate nor show any pathogenic effect. Also baculoviruses are model organisms for molecular biology studies of gene structure and organization. Although baculoviruses are used commonly, their genome replication is not understood. Most of the research data about this subject have been obtained during recent years. Human beings have just begun to benefit from the use of baculoviruses. Baculoviruses will serve science in the future as mentioned above. We believe that this review will contribute to the appreciation of the field in our country in regard to baculoviruses which are popular all over the world. For this reason, in this review after giving information about the biology of baculoviruses, replication of baculoviruses has been explained in detail.

Keywords: Baculovirus, Replication, Viral vectors